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Título : Guillain–Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1
Autor: Jaramillo-Valverde, Luis
Levano, Kelly S.
Villanueva, Isolina
Hidalgo, Meylin
Cornejo, Marco
Mazzetti, Pilar
Cornejo-Olivas, Mario
Sanchez, Cesar
Poterico, Julio A.
Valdivia-Silva, Julio
Guio, Heinner
Fecha de publicación : 28-ago-2019
Resumen : Background: Guillain–Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17, and/or ICAM1 had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. Methods: A total of nine nonrelated cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17, and ICAM1. Results: We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p '.047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. Conclusion: ICAM1 polymorphisms might be considered as potential genetic markers of GBS susceptibility. Further studies with larger sample size will be required to validate these findings.
Palabras clave : Guillain-Barre syndrome
Genetic polymorphism
Editorial : Wiley
URI: https://hdl.handle.net/20.500.12815/196
DOI : https://doi.org/10.1002/mgg3.960
Aparece en las colecciones: Artículos Científicos

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